yes shopify runs on truffleruby. It is the fastest ruby VM by far and can seamlessly call state of the art Java libraries.
GraalVM is the VM to rule them all and unify currently incompatible billions of dollars libraries ecosystems.
Despite being the computer science breakthrough of the decade, people are not getting it yet.
I don't think doing exercise trigger an inflammatory (immune) response although I might be wrong. Either way your point stand regarding its paradoxical effect on oxidative stress.
An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level.
So a ~flatline vs a sinusoid. It could be pharmacologically simulated.