Knowing the ridiculous U.S. tax laws (e.g. you once had an Green Card and now they want to tax you pretty much for the rest of your life regardless of where you live and work), overboarding bureaucracy and general lack of legal security (e.g. frivolous patent lawsuits), I would certainly open my business pretty much anywhere else.
One thing you notice right off the bat: Its very slow. It takes about 2s on my machine to load the TodoMVC example. Thats about as long as it takes to load my GMail inbox. Thats pretty horrible for whats supposed to be the "Hello World" of JS frameworks. I didnt dig in what actually takes so long, but it seems like it has still some way to go.
I find it interesting that after Angular this would the second (3rd if you count GWT) JS framework released by Google with pretty bad performance characteristics (if it actually is made be Google).