This article is an ouroboros of self-citation and speculation. The lead author, McCullough, is a known proponent of Hydroychloroquine, denier of asymptomatic spread of covid, and a paid, invited speaker at right wing and anti-vaxx conferences (see his Wikipedia for citations: https://en.wikipedia.org/wiki/Peter_A._McCullough). This "research" paper offers lots of speculation, and very little data. The number of times these authors made unfounded and spurious confusion spurious is too high to mention all of them. I'll call out one example -"There were 3,657 cases of anosmia (loss of smell), clearly
demonstrating that the SARS-CoV-2 spike glycoprotein from the injec-
tion in the arm was reaching the olfactory nerve." None of the authors are qualified to make this claim, the authors made no attempt to rule out confounding factors like prior Covid-19 infection, and no direct evidence for thistle claim was presented. Tl;Dr - the article is bad science and should be ignored
I'm a little confused why the NHMFL home page ended up in my hacker news RSS feed, but I received my PhD here and thus feel obligated to comment and upvote...
PhD in molecular biophysics here (did virology rotation in grad school also). There's not enough time to go into how bad the "science" is in this paper. Evidence is cherry-picked, and circumstantial at best. Lots of non-sequitors presented that are unconnected to the actual science. I've read earlier claims that are similar to this and basically they see low alignment similarity to commercially available vectors and claim "AHA it must be engineered". But anyone who has studied molecular biology knows that vectors are almost always derived from natural viruses. Also, while viral linkages are normally linear, crossover between viri in hosts is well documented and does occur "rarely". That's say it's rare compared to normal genetic drift, but common enough that it's not particularly surprising to see genetic material from another "vector" in the wild. It does not have to be lab derived to see the mutations observed. Once you call into question this fundamental premise, everything else looks like the scientific trash that it is.
The major (and really only) criticism of Finder is a lack of an "address" bar. I would really like a bar where I can change directories quickly instead of doing ALL navigation using mouse clicks. Yes, I know you can invoke a Command-Shift-G to do this in a secondary menu, but Explorer has this built in. Having an address bar with tab completion and unix file-system shortcut support (i.e. "~", ".", "..") would be great!
In the terminal (iterm2 of course), I find vim with the solarized theme (http://ethanschoonover.com/solarized) combined with he right plugins to be a beautiful and useful text editor. In the gui, I really love sublime text (http://www.sublimetext.com/). Atom is also quite nice, so you really can't go wrong with that
I assume you want a desktop computer? Dell has great hardware support for debian/ubuntu and RH/Cent OS. I (think) you can purchase a desktop without an OS from their SMB store. Definitely get something with a spinning platter and pop in your own SSD. It will save you a lot of money.Why not build your own desktop? If you want to get the best deal and guaranteed hardware support, read some component reviews on http://www.phoronix.com/ and put it together yourself. Good luck!
I posted an edit to my original comment. I meant that the equivalent defining of a function (in zsh) does work, but zsh -c won't run the function unless you permanently add the function to your env.
Good call. I posted an edit to my original comment. zsh -c won't run the function outside of the current session. The "extra step" needed to add functions to the environment variables seems to make zsh much more secure than bash in the context of this discussion (perhaps?). This SE thread was really helpful to me in clarifying: https://unix.stackexchange.com/questions/33255/how-to-define...
I just tried this in zsh 5.0.6 (x86_64-apple-darwin13.3.0). It reports vulnerable as well.
edit: Yes, this feature works when formatted correctly for zsh as "function ls () { echo vulnerable }". However, I was wrong in that zsh -c will not run the function (of course running "ls" in the same session will). I'm going to call this not a problem.
edit: When trying this one-liner in zsh: "env x='() { :;}; echo vulnerable' zsh -c 'echo hello'" (as suggested by https://superuser.com/questions/816622/does-the-shellshock-b...), the output indicates my shell is vulnerable. Could someone please try and replicate?
New rfid applications would be great and by means pursue them! The reason I think this is a great problem for CV is that right now, only a nurse would be able to tell if there is a puddle on the floor from a leaking IV, patient's puke, overflown catheter bag, etc. Also is there air in a line, does the label on the drug match the prescription in EMR? These are common sense, cheap to fix / prevent problems that I'm not sure rfid could solve. RFID would be great for matching drug labeled with rfid with chip in patient's armband. One could think of lots of implementations for that sort of thing!
I guess it really comes down to what sort of focus you want your project to take, and what idea you think your PI will be interested in considering. Good luck!
Sexual selection is a huge area of research in evolutionary biology. You don't have to like the wikipedia article, but a quick search on google scholar on the term reveals over 2M+ results. Check it out. Peter's description of sexual selection was much better than mine, so thanks! I brought up the Giraffe's neck because its one of the best examples of bad scientific method leading to incorrect evolutionary conclusions. Giraffe males joust as a dominance ritual prior to mating, and generally the giraffe that can exert more force will win and hence mate. There are no advantages to the neck outside of this ritual as far as anyone has been able to determine, hence it is understood to be a purely sexually selected trait.
I'm running OSX mavericks 10.9.5, use zsh as my default shell, and have a patched version of bash build from homebrew repo set as secondary in /etc/shells (on the occasion I need bash, I like to have completions). System bash is still vulnerable. With my current configuration, how worried should I be?
This really depends on how practical you want to get. One of the biggest problems in hospitals is (lack of) staffing. Having a robot that could go around the rooms and check on low-level, treatment related problems would be a huge improvement in patient care. Imagine using CV to check on IV pumps for flow rate, how much of the drug is left, is it leaking, does the patient need more IV fluids, does the name on the drug label match the patient's, etc. These are low level problems that can lead to injury and death of patients in hospitals, and usually handled by overworked nurses. Seems like a perfect application of CV to me.
While the fact that cross-over during meiosis does in fact contribute to increased genetic diversity leading to resistance to disease, parasites, and other adaptational advantages, one still needs to answer why did sexual reproduction evolve at all? Bacteria and protists are quite good at promoting genetic diversity through horizontal gene transfer, and viral infection with natural DNA replication error rates provide enough sources of "random" genetic variation to keep a diverse gene pool. One can think of competition to share genetic material as a primordial form of sexual selection. Getting from this kind of competition to orchestrated sharing and cross over of large genomes is a huge jump. The real question may be, did increasing organismal complexity necessitate a different type of reproduction to maintain genetic diversity? The answer to this may be yes, but alternative, less sexy hypotheses have to be tested as well. Another question to answer would be – What evolved first: multicellularity or sexual reproduction?
Its generally understood that traits that encourage reproduction regardless of whether or not they encourage fitness will outperform other traits (https://en.wikipedia.org/wiki/Sexual_selection). This is why you will see the appearance of coloration and seemingly useless adaptations faster than actually beneficial traits within a population (i.e. a giraffe's neck; its not for reaching those high leaves). Natural selection is generally concerning traits that promote survivability over time, a much slower process. A major hypothesis is that sexual selection may be a driving force behind differentiation of the sexes, probably originating from genetic information sharing among single-celled organisms. A competing hypothesis is that there is an intrinsic advantage to sexual reproduction versus asexual reproduction. I generally favor the former hypothesis because it generally fits the "short-sightedness" principle of evolution.
This paper makes a 0th order assumption that there is an inherent advantage to sexual vs asexual reproduction. There are certainly advantages to both, but the author is correct that the answer may come out of addressing complexity. Algorithmically, there are many approaches to modelling sexual selection (rather than natural selection). Sexual selection occurs much faster than natural selection and may be one of the reasons why we have such apparent gender differences within species. Describing the effect of complexity in terms of "fitness" is one of the largest challenges faced by computer scientists and biologists this century. If you are interested in exploring some different algorithmic models, "Computational Molecular Evolution" is an excellent book (http://www.amazon.com/Computational-Molecular-Evolution-Oxfo...).
There may be a story behind this post as it feels quite personal, but this is a pretty good composite of bad management behaviors. I see this more of a collage than a specific rant. I could be wrong, but I've seen one or more of these traits expressed by almost any supervisor I've encountered (not all the time or all at once).