It's more comfortable, but you have to be willing to learn the layout or develop your own.
I have a bastardKB Charybdis Nano as my daily, and I'm developing my own low profile board too. My next iteration of both will be 34 key only, that's plenty for me.
Same here, I ditched mac for Framework, tried Windows, nope, fans always on, Ubuntu, battery died when lid closed in < 2 hours and fingerprint scanner didn't work. Fedora, same issue. I sold it and bought an M1 Pro. Nothing wrong with it so far. OK it was 3 times the price, but you get what you pay for.
I have done just this, Dactyl Manuform with trackball custom generated with clojure (horrible) and trackball brutally added in meshmixer then 3d printed at home, it's fantastic. The fun starts with firmware.