Would not any human-devised outcome, no matter how intellectually superior its capacities, ultimately be secondarily dependent on the same metabolic laws as humans, even if in a different order of magnitude? I mean those delimiting laws would not disappear. Their indefatigability is powered somehow, and our fatiguability is adaptive.
Perhaps a loss of power and relevance of the human masses will give rise to a renewed reverence for and recognition of the fading beauties of human frailty, similar to the romantic movement following the industrial revolution. In such a setting, where we hand tech and science off to the machines (or they seize it), the profit model will be in the humanities.