Technically accurate, but the headline is misleading. The loss was because of a non-cash write-off of a transaction made a few years ago (2007-aQuantive).
Microsoft's core businesses, especially Office, are humming along. The franchise is pretty strong and the overall company is a cash generating beast.
Always stay out of your comfort zone. Never give up. Never stop improving. Measure everything of significance.
It's not a quick fix or a cure all, but I think it's helpful to internalize whichever of these points resonates with you and actively apply it in your life. You have to execute and that's the hard part.