I'm using ZFS right now, because I need something that cares for data integrity, but the fact that it will never be included in Linux is a very big issue for me. Every time you upgrade your kernel, you have to upgrade the separate modules as well - this is the point where bad things can happen. I will definitely be looking into Btrfs once it is more reliable. For now I'm having a bit of a problem with SSD caching and performance, but don't care about it enough for it to be relevant, I just use the filesystem to store data safely and ZFS does an OK job.