Q1 - How much effort did you put into deterministic guardrails like AST linters, etc?
I find there’s a ton of slop unless hard guardrails are added, eg step 1 is just around syntax, step 2 is to enforce mental models
You still need someone steering direction and have a logically consistent idea of what you actually want to build
Q2 - I find that vibe coding really accelerates FE projects because it’s possible to run everything locally and check results
For pure distributed infra backend more investments have to be made into the devloop to be able to shift left the feedback loop and decouple it from humans or real deploys
NIH should build more institutes in cheaper areas (eg not NoVa). It’s a win win since it will help revitalize poorer areas of America and save on costs.
It will also tilt more senators/congresspeople to vote for NIH funding, similar to military base funding
Any publicity is good publicity. Sprinkle in some words about "this needs further study" and hope someone comes along to fund the next few years of your lab.
Their claims around Type IIS assembly are also suspect. eg in Golden Gate assembly, you choose Type IIS that reach over and cut, so the restriction site is absent from the final assembled product.
"Additionally, because the final product does not have a Type IIS restriction enzyme recognition site, the correctly-ligated product cannot be cut again by the restriction enzyme, meaning the reaction is essentially irreversible"
The choice of focusing on a particular RE pair also smells of p-hacking. Their claim that BsaI/BsmBI makes for easy mixing/matching genomes doesn't make sense in this day and age, when you can use other techniques to make hybrids more effectively (eg, you are not restricted to the natural location of those restriction enzyme sites)
There is a huge variety of viruses, just because someone wrote the equivalent of "Hello World" doesn't mean you can write a complicated CMS anytime soon.
Synthetic biology (the actual synthesis of DNA) has come a long way, we don't understand all the components yet though.
In general, Americans don't want to pay a huge cost upfront for some efficiency gains. Especially since traditionally fossil energy was cheap.
Also look at heat pump clothes dryers. They're a win in that you don't need a vent (and associated vent cleaning), but they cost more upfront.
Hopefully these are areas where the government can provide low interest rate loans upfront, since they are investments that pay for themselves over time.
On FB, more people on the social network means the draw to the n+1st user is immense.
Whereas for home batteries, it could be the inverse. As more people have batteries, the payout is lower.
I’m all for home batteries, but I think we also need to restructure utility incentives in america. Currently they get to pass down all sorts of charges/fees to the customer.
I think you’re conflating the UI of Amazon with the more difficult problem of getting a large distributed system to work at scale.
Conversely, if your ECU has minor glitches, will you notice? Unless it results in catastrophic failure, you will not even know if happens to result in the occasional 0.1 mpg increase in consumption.
And I’m sure VW and the other companies put a lot of resources into software engineering the exhaust emissions defeat workaround.
says the study’s senior author, Xuanhe Zhao, professor of mechanical engineering and civil and environmental engineering at MIT.
The study also includes lead authors Chonghe Wang and Xiaoyu Chen, and co-authors Liu Wang, Mitsutoshi Makihata, and Tao Zhao at MIT, along with Hsiao-Chuan Liu of the Mayo Clinic in Rochester, Minnesota.
It's likely all or most of the researchers were immigrants/foreign. And yet we have overly restrictive immigration policies for high skilled workers that basically means we educate them and then return them back to their country.
Your local restaurant with thin margins and underpaid staff is an SME