Yes, but the way that I see it, if some JS function that TiddlyWiki relays on is deprecated (for example) then your Tiddly html could not work anymore, regardless of the browser. You don't have that limitation with markdown files, which are still readable in txt form.
Again, only my opinion.
I tried it for a project and I was pleased with what I could do with it (links to other inner sections, web formatting, etc).
However, i couldnt maintain this approach for new projects and daily notes, so i switched to Docsify and markdown a month ago. Docsify needs plugins to accomplish most built-in TiddlyWiki stuff (search, last updated subtitle, etc) and basically forces you to script your way to make a document structure and a working sidebar, but at least I find it less platform-dependent and more customizable.