I was trying to understand how to do this, and I formed the opinion that most of the battery providers don’t really allow the degree of ‘on/off’ or ‘charge/discharge’ customisation as might be necessary to make this work? Or was I fooled by the packaged products that are aiming to turn me and my battery and panels into a residential power plant at the whim of the energy company?
You know what already detects breast cancer? Mammograms followed by ultrasound.
We have screening programs for a reason. We know the sensitivity and specificity of these. They are widely available in any rich country that doesn’t treat its citizens like shit. There will absolutely be better stuff out there as we progress, with better sensitivity/specificity and lower harm (everything medical has some harm quotient) but I have a hard time wrapping my head around how they will best physics to provide better than state of the art today with this technology (and bow they will beat availability of current screening systems)
My impression isn’t that they are trying to improve CTE imaging (did it say that in the article?!) but somehow approach the resolution of being able to run the blood flow data through a black box so they can demonstrate what the occipital cortex is processing. I mean, that’s literally the first part of the article?
Can MRI/CT demonstrate CTE.
Well, like a lot of things which as alzheimers, that is still a pathological diagnosis for the most part, to the best of my knowledge (not post mortem scanning but out some brain tissue on a slide), but this belies the general fact that getting the tissue diagnosis is really not that important to anyone except a pedant, because yes MRI will show changes in grey/white matter differentiation and size compared to age and sex weighted cohort; and CT will show similar; and in fact it is the history and examination that practically matter to both the patients and their family.
So while it’s nice to have a totally 100% bulletproof ‘diagnosis’ for labelling purposes, practically on history and exam it’s not going to change how they are managed or what they and their family do say to day; given that both CTE and basically any of the dementias don’t have any treatment associated with them, and the current neuro imaging we have can deliver much higher resolution than what this is promising anyway (I mean even CT angio, and it’s not using ‘advanced imaging processes’ to create data out of noise)
The methods described in the main article refer specifically to neurovascular imaging. In order to have a higher resolution, they’re making use of microbubbles (which need to be prepared and injected just prior to imaging).
There is no world where vascular imaging with a methodology like this is better than what I can do today in a GP clinic with a handheld GE or butterfly (or similar) US probe for anything that matters:
- for dvts and thrombus I can already image them
- if it’s in the brain the last thing that is useful for you to do is fuck around in a small clinic when you should be getting to a major tertiary centre as soon as possible
I am a huge Tchaikovsky fan, mostly as I love his hard sci fi and incredible world building. I normally shy away from any fantasy but his city of last chances trilogy (now turning into a quadrilogy/on its was to 5??) is one of the absurdist Pythonesque and actually funny series I’ve read in years (although the first one is legitimately hard to parse/read given the style). Still, the juice is worth the squeeze and the second in the series I found hilarious.
I got a student subscription to cursor and after giving it a good 6 hours I’ve abandoned it.
I extremely dislike the way it goes forth and bolts. I don’t trust these tools enough to just point it in the direction and say go, I like to be a human in the loop. Perhaps the use case I was working on then was difficult (quite old react native library upgrade across a medium sized codebase) but I eventually cracked this on Claude; cursor in both entropic and Gemini left me with an absolute mess.
Even repeatedly asking the prompt to keep me in the loop it kept on just running haywire.
The difficulty is stopping when control of the organism is actually achieved, not just when you ‘feel better’. Most people are totally unable to make this judgement
Huntingtons is not unique but certainly notable because it is caused by repeat sequences and therefore uniquely suited to mRNA silencing in this manner. There are very few other progressive (and I presume you also mean neurological) conditions, but also applied to the rest of the body, where this is the pathophysiology. For example, currently there is no immediate expansion of this to ie Parkinson’s (different pathophysiological basis) Lewy body (although maybe?) alzheimers (again possibly depending on whether it is tau, amyloid beta or simply ‘type 3 diabetes’) and nothing whatsoever for vascular dementia or ALS
Have a read (rather than guessing) - it’s fascinating! Your other reply has a good insight but on more of a related topic but the primary reason this exists is for error correction. So approx one third of single nucleotide mutations have no change on the expression of the DNA or protein. And some of those that do change the amino acid are actually conservative; ie changing a basic amino acid to another basic amino acid which may still end up folding in the same way
Bad guess, I am not sure what OP really intends (perhaps you don’t consume whilst you sleep?!) because as you probably are starting to remember from primary school your body maintains homeostasis by continually respiring. It doesn’t suddenly decide to take a dump.
Ok, it does, but even when it does that, in order to do that it has been continually maintaining homeostasis
There is no issue with countries buying us treasuries. They sail off shelves. Until the current administration started to make it look like there’s a possibility that the country may bankrupt itself, which threw a risk component into US debt for like the first time ever
The characteristic ‘jagged lines’ of aura is not at all related to the characteristic visual flashes of retinal detachment which an entirely different pathophysiology. Given that the advent of the flashes are new and related to exertion however it wouldn’t be unreasonable for the OP to keep a log of onset and duration and consider neurologist referral if they were to become more common with consideration for screening imaging as there are certain conditions related to exertion that can trigger aura
The levels of fluoridation in order to cause difference in IQ as I understand it, from the Chinese studies, suggest that basically the effect if true occurs at around 2x+ the concentration found in supplemented water supplies.
My understanding also is that if you’re a dentist wanting to get rich, move somewhere that has unfluoridated water.