I had CFS like symptoms so bad I was stuck in bed for several years and the doctor basically would not help me. Eventually I decided to treat it myself with antibiotics and anti parasitic medication. I basically came to the conclusion that for my specific case I had an unknown blood parasite and the fatigue was being caused by neurotoxins. I don't think all CFS are caused by an infection but mine definitely was and I have my life back. If you a researcher looking for a cure, try to test medications that flush neurotoxins out to see if the disease goes away and then try figuring out what is creating them in the first place to treat them.