For me the biggest problem with edit-and-continue in Visual Studio is that you can only edit code when program is paused at breakpoint. You can't change drawing routine formula and observe effects on animation on the second screen. I've seen Notch doing that in Java and it was cool. In VS you get "Changes are not allowed while code is running" error when you start typing.
Even php/javascript feels more interactive than C#, just press F5 and watch the page change. In VS ASP.NET you have to restart whole site (10x longer).
Also edit-and-continue works only for very local changes.