You'll really have to qualify "quality of life," besides the crime rate. And as urban crime rate goes.. it's honestly middle of the road as far as major American cities go, comparing favorably to LA, New York, Boston, and Washington in most categories. (http://en.wikipedia.org/wiki/United_States_cities_by_crime_r...)
Anecdotally, I live in Washington but just spent a week out there never leaving SoMa/Market Street/Tenderloin, and felt about as comfortable there as I do in the up-and-coming areas of DC. e.g. just be aware of your general surroundings.
Shout to all my lost boys? ("Rob Portman resembles Oliver Twist.") We rowdy!