Dietary restriction of isoleucine increases healthspan and lifespan of mice(cell.com)
cell.com
Dietary restriction of isoleucine increases healthspan and lifespan of mice
https://www.cell.com/cell-metabolism/abstract/S1550-4131(23)00374-1
3 comments
This is so peculiar. If the body plans to die then maybe you can interfere with it. eeveryone just assumes the body would live forever if it could but that would t agree with the value of sexual production.
Cells die before they turn to cancer. Same with the individual. We have limited useful lifespan. Above that we’re a burden on society.
Unless we can keep peak performance indefinitely. Think of all the thousands of specialists that die each year carrying with them an immense amount of acquired knowledge.
That's not at all how our lifecycle works.
We grow up young, inexperienced, eager to learn, eager to try things and fail, our metabolism is much higher than needed, in order to compensate for this frantic phase of our lives.
Then as we settle, and slow down, the best are selected and assigned positions of responsibility. As they carry out their tasks, they get set in their ways and learn less, and repeat more. Eventually they become outdated, and need to be replaced with the next generation, or they begin to stall progress by insisting their way is better.
It's not an issue of health, it's an issue of entropy. Our brains are not designed to learn forever. We do learn a bit to the day we die, but not deeply. To learn forever, the way you learned as you were young, means you constantly risk losing yourself. This is dangerous when you're in a position of power. You need to reduce mutability as you increase your leverage, to maintain a steady course into a known direction everyone can follow along with.
You can't be a careless child and an adult leader at the same time. Those are incompatible roles. They have the extreme opposite of requirements.
There's no such moment of "peak performance" that you can hold onto. It's a wave, an oscillation. You're born, you grow, you learn, you're selected, you give back, then you retire to be consulted by the next generation only when they need you.
If thousands of specialists die before they give what they found useful to the next generation, they've failed at their purpose.
To record knowledge, to replicate it, we have speech, spoken, written, visual media, telephony, internet, videos, media in general. We have everything we need.
But it's the role of the next generation to take this in and refract it through their always evolving understanding.
Nothing is static. Only immutable nothingness is static. Unchanging. To try to hold onto something forever, unchanging, to live forever, is the same as death.
We grow up young, inexperienced, eager to learn, eager to try things and fail, our metabolism is much higher than needed, in order to compensate for this frantic phase of our lives.
Then as we settle, and slow down, the best are selected and assigned positions of responsibility. As they carry out their tasks, they get set in their ways and learn less, and repeat more. Eventually they become outdated, and need to be replaced with the next generation, or they begin to stall progress by insisting their way is better.
It's not an issue of health, it's an issue of entropy. Our brains are not designed to learn forever. We do learn a bit to the day we die, but not deeply. To learn forever, the way you learned as you were young, means you constantly risk losing yourself. This is dangerous when you're in a position of power. You need to reduce mutability as you increase your leverage, to maintain a steady course into a known direction everyone can follow along with.
You can't be a careless child and an adult leader at the same time. Those are incompatible roles. They have the extreme opposite of requirements.
There's no such moment of "peak performance" that you can hold onto. It's a wave, an oscillation. You're born, you grow, you learn, you're selected, you give back, then you retire to be consulted by the next generation only when they need you.
If thousands of specialists die before they give what they found useful to the next generation, they've failed at their purpose.
To record knowledge, to replicate it, we have speech, spoken, written, visual media, telephony, internet, videos, media in general. We have everything we need.
But it's the role of the next generation to take this in and refract it through their always evolving understanding.
Nothing is static. Only immutable nothingness is static. Unchanging. To try to hold onto something forever, unchanging, to live forever, is the same as death.
It’s not just iso. Also leucine, valine, theobromine and methionine have evidence that they extend lifespan when restricted.
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