Its mathematically derived. A0 is exactly 1m2 in area. The side lengths are at a ratio of sqrt(2), that means you can cut any A paper size in half and get the size below it. B series are the same ratio, but B0 has a width of 1m instead.
I'm not an expert in pharmaceutical chemistry, but this looks like a series of relatively complex and low yield reactions. Would it be likely that this would push the price of this product beyond what is reasonable for a general use drug?
A bit outdated now, but Saturn TAS made a very good TAS. It optimized door transitions to get the best in-game time. Unfortunately this was right as the rules changed between tracking in-game time and real-time, so the run never made it into the leaderboard. It made him stop making TASes for Super Metroid altogether.
https://www.youtube.com/watch?v=y3THRhCgCO4
Where i live, 80% of all vehicles are passenger vehicles. I'm not sure that the extra wheels on semis would make up for that difference, especially with the slow increase in size of passenger vehicles.
I used to follow the development blogs of the witness. I remember reading somewhere that accessibility was why you can beat the game with only 7/10 sections complete. You can completely skip both the colour puzzles and sound puzzles and still finish the game. Its an interesting compromise.
As someone who is colorblind, you are correct. Those puzzles are just about impossible for me.
I have read 'How to disappear', i don't think it would be very useful here. It's written by two private detectives to help people evade stalkers or family violence. It specifically recommends against breaking the law. In any case it would be a bit out of date by now.