Nicotine itself may not be a carcinogen, but its metabolites are.
Nicotine itself has been demonstrated to be a tumor promoter by way of increasing tumor cell division in lung cancer and inhibiting apoptosis.
Quoting chemical highlight 25-1 from "Organic Chemistry" 6th edition by Vollhardt & Schore:
Nicotine appears to play a dual contributory role, because its metabolites are outright carcinogens and because the parent system itself, while not causing cancer, is a tumor promoter.
The metabolic pathway has as the initial step the N-nitrosation of the azacyclopentane (pyrrolidine) nitrogen. Oxidation and ring opening (compare Chemical Highlight 21-3) then take place, giving a mixture of two N-nitrosodialkanamines (N-nitrosamines), each of which is a
known powerful carcinogen.
Upon protonation of the oxygen in the nitroso group,
these substances become reactive alkylating agents, capable
of transferring methyl groups to nucleophilic sites in biological molecules such as DNA, as shown below. The diazohydroxide that remains decomposes through a diazonium ion to a carbocation, which may inflict additional molecular
damage (Section 21-10).
As luck would have it, I tried Antigravity for the first time a few days ago.
It was a complete buggy mess - at one point I asked Gemini why it could not use the network despite having network access enabled in the sandbox settings, and it told me that although it had network access, it couldn't use mdnsresponder while running with the built-in sandbox. Like, how well thought out, network access without DNS.
After burning through about 80% of my 5-hour window of credits, I finally just went sandboxless to get the thing running. It hit the limit pretty quickly. I waited until the 5 hour limit was up, and found the 5 hour window had morphed into a one week window, still drained of credits.
I thought at least I can keep on using Gemini CLI until Google figures out this Antigravity thing. Oh well.
> Blocking the right car lane for a drop off is perfectly legal outside of No Stopping zones.
In which municipality?
In most cities and states in the US, it is illegal to obstruct a roadway. Taxis may get some carve-outs for loading and unloading disabled people, but usually, even taxis are supposed to pull over before stopping for a passenger.
One of the often-overlooked terms of use that people ignore when accessing a payroll processing / human resources website is that the company providing those services can "share" your data with "trusted partners" which essentially allows them to move your income and other personal information to other entities which, in turn, sell that information to anyone who is willing to pay.
It's one of the more abusive uses of click-through agreements - in order to get paid, you have to login and setup your payroll information, and in order to login, you have to click through and agree to these terms, and there is no way to opt out during or after the process.
Whenever you see a "high-fat diet" study, you can usually translate that to "hypercaloric diet" study, and this one is no exception.
One fly food was 8% glucose (.308 kcal/g) and the other was 8% glucose + 20% coconut oil (.308 kcal/g + .7136 kcal/g = 1.0216 kcal/g) leaving the high-fat arm with 332% of the caloric density of the standard fly food diet. The discrepancy clouds how much of the observed effect is due to the coconut oil, and how much is due to the difference in caloric density.
I looked into how well fruit flies self-regulate caloric consumption, but all that I could find was related to carbohydrates and protein. It would seem that fruit flies don't typically eat much in the way of fats, presenting another confounder in the results.
I’m curious if you consulted with an attorney about that? I’ve heard the opposite from people looking to move from Chicago to CA. Does your former employer have a nexus in CA?
Using Florida as an example, if your contract was signed in Florida, your former employer is in Florida, and your case is tried in Florida, the courts aren’t going to pay any regard to California law, and you can be found liable for breach of contract and damages. Correct me if I’m wrong.
I have been wanting to get my genome sequenced for years, and had been thinking 23andme might be one of the better options because of the possibility of invoking the CCPA to get my data deleted after sequencing. Never did it because I wonder if they sell your info to some third party the second it comes off the sequencer, and also because I'm skeptical that they would fully comply with a deletion request.
For people who would like to get their DNA sequenced but are actually concerned about privacy, are there any better options?
For anyone interested in on-the-wrist blood pressure tracking who doesn't want to spend the money on a Samsung Galaxy and hack SHMs, or wait for Apple to implement it, there are a plethora of Chinese smartwatches that already have the blood pressure monitoring and calibration capability that can be had for < $15.
My experience with them is that although I wouldn't trust these to diagnose a medical condition, the trends are correct and correlate to cuff readings - they're not just random number generators.
I just wish there were a way to export the data from the H Band app. Apparently, the data is stored in SQLite files.
Were the people with high BMIs actually on a high-fat diet? The premise here is that mice fed a high-fat diet serve as a model for people with a high BMI, but any hypercaloric diet will lead to a high BMI.
The original justification that Nvidia gave for removing Nvlink from the consumer grade lineup was that PCIe 5 would be fast enough. They then went on to release the 40xx series without PCIe 5 and P2P support. Good to see at least half of the equation being completed for them, but I can’t imagine they’ll allow this in the next gen firmware.
> now some cars don't even come with the little donut wheels
Those cars come with “run flat” tires, which supposedly allow you to drive a few miles without damaging the wheel when the tire is flat. After which, instead of patching the tire, it must be discarded. Quite the advancement.
Who in their right minds lends to a PE-owned company? You know they’re going to raid the piggy bank and leave the lender holding the bag. There can’t be that many rubes with $450 million laying around. Are the investors government pension funds or something?
Quoting chemical highlight 25-1 from "Organic Chemistry" 6th edition by Vollhardt & Schore:
Nicotine appears to play a dual contributory role, because its metabolites are outright carcinogens and because the parent system itself, while not causing cancer, is a tumor promoter.
The metabolic pathway has as the initial step the N-nitrosation of the azacyclopentane (pyrrolidine) nitrogen. Oxidation and ring opening (compare Chemical Highlight 21-3) then take place, giving a mixture of two N-nitrosodialkanamines (N-nitrosamines), each of which is a known powerful carcinogen.
Upon protonation of the oxygen in the nitroso group, these substances become reactive alkylating agents, capable of transferring methyl groups to nucleophilic sites in biological molecules such as DNA, as shown below. The diazohydroxide that remains decomposes through a diazonium ion to a carbocation, which may inflict additional molecular damage (Section 21-10).
You can read more at https://archive.org/stream/VollhardtOrganicChemistryStructur...