> Osteoarthritis occurs when a joint is stressed by aging, injury or obesity. The chondrocytes begin to release pro-inflammatory molecules and to break down collagen, which is the primary structural protein of cartilage. When collagen is lost, the cartilage thins and softens; the accompanying inflammation causes the joint swelling and pain that are hallmarks of the disease.
Collagen synthesis in the human body can be aided by hydrolyzed collagen, Vitamin C, zinc and copper.
What advice would you give to a younger L. E. Modesitt, Jr. at the beginning of his writing career?
> I wouldn’t even try. I like where I am, but getting here was so unplanned that any advice given to me at that age likely would have ruined me or made the journey seem so impossible that I might not have even tried.
In theory, LLMs could review more sources for a personalized risk assessment. But a brief query on this subject yielded generic responses from multiple LLMs :(
The smallest capsule of pregabalin/lyrica is 25mg. After reducing to that minimum, it still took months of further tapering by dividing capsules, before withdrawal symptoms ended in one elderly patient. Pregabalin suppresses nausea, which means nausea is a symptom of withdrawal, requiring ginger tablets or other anti-nausea assistance during tapering.
> An investigation by The Sunday Times has revealed that pregabalin has the fastest-rising death toll of any drug in the UK, based on figures compiled from official data across all regions. It is detected in a third of all drug-related deaths. In 2012, pregabalin was indicated in nine fatalities. A decade later, in 2022, the number had risen to 779, with almost 3,400 deaths in the past five years.
The widespread use of Gabapentin and Pregabalin to treat neuropathy is off-label their original function as anti-convulsant and anti-psychotic meds. In addition to the documented negative side effects, withdrawal by elderly patients from extended use can be difficult, even with months of tapering. They can negatively affect memory and cognition.
> Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat neuropathic pain and also for partial seizures of epilepsy.. is [ONLY] moderately effective: about 30–40% of those given gabapentin for diabetic neuropathy or postherpetic neuralgia have a meaningful benefit.
Those with peripheral neuropathy should audit the total amount of Vitamin B6 in their diet and daily supplements. Try to keep the daily amount below 10mg. There have not yet been lawsuits to add bottle label warnings, but Australian regulators have issued a safety warning.
> Vitamin B6 (pyridoxine) is in lots of multivitamin and mineral supplements that can be bought in supermarkets, health food shops and pharmacies without a prescription. Many people are not aware that vitamin B6 can cause peripheral neuropathy, which results in tingling, burning or numbness usually in the hands and feet. Taking vitamin B6 even at low doses can cause peripheral neuropathy but people are more likely to get it if they are taking more than one supplement.
> Identify or find objects with Alexa+.. use the camera on Echo Show devices to identify objects and get help with daily tasks. For example, reorder pantry items by showing them to the new Alexa, ask Alexa to identify a type of plant and its care instructions and set reminders for when it needs to get watered, or get fashion or décor ideas. This new feature is particularly game changing for people who are blind or have low vision
This has so much potential, but it will require a workflow for Alexa to learn about specific objects and layout (of multiple objects) within the customer's home. Apple's "live audio descriptions of video" had similar promise at launch, but hasn't evolved beyond the launch demo, https://support.apple.com/en-ca/guide/iphone/iph32deb9296/18.... Could Alexa+ enable self-service RLHF on home video/images?
It's a testament to the latent market opportunity that Amazon has sold 500+ million devices, despite the obstacles that greet customers trying to customize Alexa for their specific needs. With open developer interfaces, Alexa could have been the "IBM PC" of voice AI, instead of just another walled garden.
LibVMI-based debug server, implemented in Python. Building a guest aware, stealth and agentless full-system debugger.. GDB stub allows you to debug a remote process running in a VM with your favorite GDB frontend. By leveraging virtual machine introspection, the stub remains stealth and requires no modification of the guest.
A modern virtualization architecture can be found in the OSS pKVM L0 nested hypervisor for Android Virtualization Framework, which has some architectural overlap with HP/Bromium AX L0 + [Hyper-V | KVM | Xen] L1 + uXen L2 micro-VMs with copy-on-write memory.
A Bromium demo circa 2014 was a web browser where every tab was an isolated VM, and every HTTP request was an isolated VM. Hundreds of VMs could be launched in a couple of hundred milliseconds. Firecracker has some overlap.
> Lastly, this approach is almost certainly more expensive. Our instances sit idle for the most part and we pay EC2 a pretty penny for the privilege.
With many near-idle server VMs running identical code for each customer, there may be an opportunity to use copy-on-memory-write VMs with fast restore of unique memory state, using the techniques employed in live migration.
Collagen synthesis in the human body can be aided by hydrolyzed collagen, Vitamin C, zinc and copper.