I interviewed at Sikorsky back in the day. Sort of wish I had pursued it, because the factory floor was amazing, but the manager reminded me of a guy from The Sopranos, and then I got into medical school. But that floor, man. Swashplates. Have you ever seen a swashplate, naked and alone on a pallet? Thin wall machining. I mean, goddamn, that was some sexy machine work. But they wanted me to run business analytics for government cost-accounting programs. Fuck. That. Also, medical school.
My first job out of college was as a junior engineering officer on a ship. I had taken naval architecture and the daily draft report was part of my job. The fuel king had a spreadsheet where the engineering watch input all the tank levels overnight. I added a sheet that took that data and solved all the tank problems, bouncy, incline, etc, and printed the report. So instead of two hours of number crunching, or one of my enlisted guys doing what he did (which was basically copy forward and subtract an inch a day), the report was completely automated, with fore, aft, and center draft. With zero human effort.
Apparently the guy who took my job when I left had a nervous breakdown. I feel a little bad about that, but not really. He should have paid attention in class.
I believe socialism has a pretty specific definition: government ownership and control of the means of production. Which is easy to grasp for steel mills, power plants, and hospitals. A bit trickier in the creative economy and the gig economy.
Unfortunately, some people are going to read this wrong. For example: I know some folks who have "second dinner" after 8 pm. Their children are definitively obese, and I can see them citing this study as a reason to keep eating "a meal called dinner" after 8 pm.
How do you propose to infect cells deep inside solid tumors?How do you target cells that have lost cell surface markers? Your example, p16, is used in many cells intermittently, or only in certain microenvironments . How do you deliver? IV, topical, tumor injection (if so, what about needle tract seeding)?
There are regions with sparse coverage due to higher concentrations of C-G bases. This can make alignment results less reliable. Plasmids may interfere with alignment or need to be isolated out before or during library prep. And you want to detect and discard any members of the population with any evidence of cancer, genetic disease, etc.
And you need good population coverage. What's a normal variant? Newer methods propose a graph alignment instead of just trying to build a single sequence reference genome.
Personal opinion based on anecdotal evidence: population mobility has increased career opportunity at the expense of the opportunities afforded to young families through staying close to home. From newborn to age N, local gandparents can be a godsend. In any family's case, which grandparents are nearby may be crucial, but if you came from a nuturing home, moving to a different timezone has definitely negative, high stress consequences in the young home.
I'd go beyond "general problem-solving skills". Physics gives you high quality math training (albeit somewhat truncated with respect to number theory), coupled with demanding experimental methods, and a deep, principled understanding of the foundations of the universe. Nothing is beyond your reach. Any other quantitative or logical discipline is just laying there, waiting for you.