> Captain and first officer are reported to have died in the accident, two fire fighters on board of the truck received serious injuries, 13 passengers received injuries.
One caveat is that regular PET isn't so good in the brain - there is so much metabolic activity that everything glows. So I get an MRI Brain to go with my regular full body PET/CT (cancer 5 years ago with recurrence 18 months later, currently NED).
As others pointed out, these are stage I trials and these are patients that have had other treatments already. In particular the melanoma patients had already had other immunotherapy - which is known to work for 50+% of cases - so this could help plugging the gap for the rest.
The testing here is not just that it is safe on skin, but the SPF test itself is done by slathering it on humans and exposing them to light to determine a rating.
Sadly Richard has now had recurrence. There is still hope for this treatment for others, and it likely extended his life, but it isn't happily ever after this time.
No chemo. The entire idea of this regime is to hit the tumour with immuno to get the reaction. They want lots of tumour cells and for it to be "treatment naive" - Richard hadn't even had corticosteroids, which dampens immune.
Once they primed his system they excised as much as possible and kept the immuno going while doing a course of radiation.
Profs Long and Scolyer work with melanoma where chemo is rarely used these days.
There's a bunch of different immuno types for melanoma (and other cancers). That one is a combo of nivolumab (aka Opdivo) and relatlimab.
Nivo is used a lot for melanoma, also commonly in combo with ipi (ipilimumab, yervoy). Pembro (keytruda) is the other common one.
Anyway, any of these can have adverse effects so patients are closely monitored.
For me, my thyroid didn't like nivo much but recovered. But we stopped after a couple of cycles of ipi+nivo because I was starting to develop colitis. And more importantly it wasn't slowing development of my melanomas.
It does launch an instance and take a snapshot but what's happening is the sysprep and OOBE stuff that can take 10 mins or so (you can find it in the console and startup logs). That's a lot more overheard than just hydrating an EBS volume.
No, us locals don't know them all either!