chiggins · HackerTrans

vor 8 Jahrendiscuss

This is an outlandish argument to make. Prop 13 contributes to shortage of housing stock. Shortage of housing stock causes prices to rise. In the event of any sale (existing property or new), the price will be higher than it would have been without Prop 13 in place. The same marginal tax rate on the new (or transferred) home now amounts to a larger amount than it would have otherwise.

chiggins

vor 8 Jahrendiscuss

After 401k, taxes, and rent, around 5-7k/mo (depends on your living situation).

chiggins

vor 9 Jahrendiscuss

Not to derail this further, but your description of Parkinson's disease is incorrect. Dopamine plays a role, but it isn't degeneration motor neurons themselves. There are many effects, but the primary symptoms WRT motor control are caused by death of dopaminergic neurons whose cell bodies reside in the substantia nigra but innervate and regulate firing of corticostriatal pre-motor pathways.

[0] I did my PhD on this

[1] https://en.wikipedia.org/wiki/Parkinson%27s_disease#Pathophy...

[2] https://en.wikipedia.org/wiki/Nigrostriatal_pathway

chiggins

vor 9 Jahrendiscuss

All models are wrong but some are useful. My PhD was in empirical protein dynamics (solution NMR, CD, DSF, etc..) and the long and short of it is that disordered states are particularly difficult to distinguish from one another. When you consider that an even partially disordered ensemble has essentially an infinite number of nearly degenerate conformations inter-converting on timescales ranging from picoseconds to milliseconds, lumping them into coil/turn/other turns out to be just the law of large numbers in action (reversion to the mean, etc.).

That and the biophysical properties conferred by partially disordered proteins makes them a motherfucker to work with outside of some archetypal domains. I liked to explain it like this. Imagine you have a piece of string three feet long. Along the length of that string you have ~1 inch segments consisting of velcro (both kinds), zippers, magnets, balloons, strawberry jello, and marshmallows--all randomly distributed along the length. Now try to fold all of that up so the jello, velcro, and balloons are on the inside. That's a simple model of a protein. Now make it start opening and closing. Now put 5 of them next to each other.

chiggins

vor 10 Jahrendiscuss

Single-tracking should have a symmetric effect, i.e. the distribution of delay for both northbound and southbound trains through the track segment containing the bridge repair should both be positive. Instead, the southbound (and to a lesser extent the northbound) trains traveling through the segment actually have "negative delay"--completely inconsistent with the alternative hypothesis. You don't need data science to show that single-tracking doesn't explain the observed data--just common sense.

comments