Not all mutations have a phenotypic effect that can be selected against. The interesting part of this study is that there is (apparently) a lack of mutations in non-coding regions.
"On-Topic: Anything that good hackers would find interesting. That includes more than hacking and startups. If you had to reduce it to a sentence, the answer might be: anything that gratifies one's intellectual curiosity."
Whilst I agree that many self-help books are poor, I think it's unfair to dismiss someone as a coach simply because they never achieved greatness. There are many examples of successful sports people who's coaching achievements far exceed their achievements as a player (Sir Alex Ferguson, Jose Mourinho or Arsene Wenger are all good examples). This is because the skills required to coach are different (although overlapping) with the skills necessary to be an elite athlete.
The quoted statement should be interpreted in the context of the study. Specifically, in the context that "species’ current ranges are not always delineated by geography".
The genetic isolation of Native Americans was clearly a result of a geography.