Lyme disease vaccine found to be safe and effective in clinical trial(newscientist.com)
newscientist.com
Lyme disease vaccine found to be safe and effective in clinical trial
https://www.newscientist.com/article/2250045-lyme-disease-vaccine-found-to-be-safe-and-effective-in-clinical-trial/
2 comments
The LYMErix vaccine caused similar autoimmune reactions to the disease in some people. There was a lawsuit, and it was pulled from the market. Hopefully the new one does not do that.
You’re inadvertently proving their point: try to find a citation for that and you’ll end up with stories circulated by anti-vaccination groups and lawyers hoping to cash in.
This was extensively studied and there’s a summary here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/
The other factor conspicuously left out is the question of what happens without a vaccine. People still get Lyme and chasing the vaccine off the market is a net loss if more people catch the disease than would have had significant complications. Those numbers don’t appear to be even close and human impact on the environment means that more people are exposed to Lyme every year.
This was extensively studied and there’s a summary here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/
The other factor conspicuously left out is the question of what happens without a vaccine. People still get Lyme and chasing the vaccine off the market is a net loss if more people catch the disease than would have had significant complications. Those numbers don’t appear to be even close and human impact on the environment means that more people are exposed to Lyme every year.
The article you quote directly supports GP's claim that the vaccine caused autoimmune disease in certain individuals:
> These findings suggested that, in patients with the DR4+ genotype, an immune response against OspA could translate into a cross-reactive autoimmune response. By implication, an OspA Lyme vaccine might result in autoimmunity in these genetically predisposed individuals. Although causality proved difficult to demonstrate, one study reported four male patients with the DR4+ genotype who developed autoimmune arthritis after receiving LYMErix™ vaccine [34].
> These findings suggested that, in patients with the DR4+ genotype, an immune response against OspA could translate into a cross-reactive autoimmune response. By implication, an OspA Lyme vaccine might result in autoimmunity in these genetically predisposed individuals. Although causality proved difficult to demonstrate, one study reported four male patients with the DR4+ genotype who developed autoimmune arthritis after receiving LYMErix™ vaccine [34].
Lyme Disease is brutal to those who have the misfortune of being exposed and it is notoriously hard to diagnose. It will likely not be required for those in low risk geographic regions, however one imagines it becoming a standard vaccine for those who are in areas where Lyme is prevalent.
As a fun twist, there are Lyme vaccines available today for dogs and horses, so the vetrenarians are ahead of the doctors on this one.