Hydroxychloroquine found to be more potent than chloroquine to inhibit SARSCoV2(academic.oup.com)
academic.oup.com
Hydroxychloroquine found to be more potent than chloroquine to inhibit SARSCoV2
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa237/5801998
5 comments
It seems like the title may be misleading:
"We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients."
This seems like:
a. This would have no prophylactic benefit (to avoid infection or reduce early symptoms)
b. The benefit would only apply to people who are already in the late stages and experiencing a cytokine storm
As hydroxycholoquine is immunosuppressant, I might suspect that its use in non-critical cases could actually worsen outcomes by suppressing the functioning immune response. As someone who was looking into it as a potential tool in the prep kit, I think this is likely a drug that is best administered only at the discretion of a doctor.
Would love to hear opinions from others who are more knowledgable though.
"We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients."
This seems like:
a. This would have no prophylactic benefit (to avoid infection or reduce early symptoms)
b. The benefit would only apply to people who are already in the late stages and experiencing a cytokine storm
As hydroxycholoquine is immunosuppressant, I might suspect that its use in non-critical cases could actually worsen outcomes by suppressing the functioning immune response. As someone who was looking into it as a potential tool in the prep kit, I think this is likely a drug that is best administered only at the discretion of a doctor.
Would love to hear opinions from others who are more knowledgable though.
"Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV."
https://www.nature.com/articles/s41422-020-0282-0 [04 February 2020, https://doi.org/10.1038/s41422-020-0282-0]
A generic anti-malarial on WHO's Essential Medicines list, about 100 times more expensive in the US (WP)
https://www.nature.com/articles/s41422-020-0282-0 [04 February 2020, https://doi.org/10.1038/s41422-020-0282-0]
A generic anti-malarial on WHO's Essential Medicines list, about 100 times more expensive in the US (WP)
In vitro, not in vivo.
But we haven't had a readout on the Chloroquine trials yet. Early results say they are promising. So, it's not a huge leap to say there is a good chance that Hydroxychloroquine is even better (based on in-vitro results) and has a better safety profile.
It's easier to buy Chloroquine online though, than Hydroxychloroquine.
It's easier to buy Chloroquine online though, than Hydroxychloroquine.
Is SARSCov2 == COVID-19?
Or is SARSCov2 ~= COVID-19?
Or is SARSCov2 ~= COVID-19?
SARSCov2 is the virus. COVID-19 is the disease.
For an intelligent, less befuddled perspective, see medcram lecture 34 https://m.youtube.com/watch?v=U7F1cnWup9M