Modafinil enhances cognition and is deemed safe by health experts(qz.com)
qz.com
Modafinil enhances cognition and is deemed safe by health experts
https://qz.com/485020/the-worlds-first-true-smart-drug-enhances-cognition-and-is-deemed-safe-by-health-experts/
4 comments
Slightly off-topic.
The journal article is tagged with "nootropic". Modafinil is not a nootropic, but a smart drug. There is a subtle but important difference between the two. Both types of drugs enhance your cognitive performance, but a nootropic must be neuroprotective. Piracetam, the first nootropic synthesized in 1964 is used nowadays to treat cognitive decline [1]
I am not saying that modafinil will fry your brain, but definitively it is not designed to protect it.
In my personal experience, Modafinil works pretty well in low doses. 25mg-50mg every 2-3 days lifts my mood and increase my work output significantly. The recommended dosage (200mg) is a crash and burn for me.
[1] https://www.ncbi.nlm.nih.gov/pubmed/16007238
The journal article is tagged with "nootropic". Modafinil is not a nootropic, but a smart drug. There is a subtle but important difference between the two. Both types of drugs enhance your cognitive performance, but a nootropic must be neuroprotective. Piracetam, the first nootropic synthesized in 1964 is used nowadays to treat cognitive decline [1]
I am not saying that modafinil will fry your brain, but definitively it is not designed to protect it.
In my personal experience, Modafinil works pretty well in low doses. 25mg-50mg every 2-3 days lifts my mood and increase my work output significantly. The recommended dosage (200mg) is a crash and burn for me.
[1] https://www.ncbi.nlm.nih.gov/pubmed/16007238
I'd hesitate to call anything that has a chance of giving me Stevens–Johnson syndrome "safe".
This reminds me of those commercials for medications that will help you with a runny nose, but have possible side effects of kidney, liver, and respiratory failure, depression, and death.
A big fat "no thanks!" from me.
This reminds me of those commercials for medications that will help you with a runny nose, but have possible side effects of kidney, liver, and respiratory failure, depression, and death.
A big fat "no thanks!" from me.
SJS is triggered by paracetamol & Acetaminophen [1] & antibiotics, among other drugs. It appears that one needs a complex set of conditions, which can occur with many drugs (including Modnafil & commonly used pain relievers, etc.).
Note that I am not endorsing (or challenging) the use of the drug to enhance cognition. I just want to understand what evidence there is suggesting a higher rate of incidence with modnafil as compared to sulpha drugs & analgesics.
Literature survey in Pubmed reveals fairly few reports [e.g: 2], describing only a handful of cases.
If the argument is: the risk of SJS is not worth the likely benefits in improved cognition, I understand. But I am not convinced if there is compelling evidence linking modnafil with SJS.
[edit: reorganized paragraphs; deleted unsubstantiated reference to allergies] [1] https://www.ncbi.nlm.nih.gov/pubmed/24527413 [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386138/
Note that I am not endorsing (or challenging) the use of the drug to enhance cognition. I just want to understand what evidence there is suggesting a higher rate of incidence with modnafil as compared to sulpha drugs & analgesics.
Literature survey in Pubmed reveals fairly few reports [e.g: 2], describing only a handful of cases.
If the argument is: the risk of SJS is not worth the likely benefits in improved cognition, I understand. But I am not convinced if there is compelling evidence linking modnafil with SJS.
[edit: reorganized paragraphs; deleted unsubstantiated reference to allergies] [1] https://www.ncbi.nlm.nih.gov/pubmed/24527413 [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386138/
Where did you find references to it causing Stevens–Johnson syndrome?
What are the chances of getting it?
What are the chances of getting it?
For an absurdist parody of this, see "Unedited footage of a bear".
"What’s lacking is long-term data—important because study of other promising enhancers has shown that the effect may not last over time."
This article fails to link to answer any of my key questions: What definition of cognition? How does it compare against caffeine in these same tests?