Terrible pop sci title that makes the work sound a bigger deal than it is. I thought that evolution of cancer under drug treatment would be described. But a more accurate title would be, Computer simulations of proteins show molecular mechanism of particular resistance mutations to imatinib that were previously characterized to increase ligand dissociation kinetics.
That is, certain mutations in the protein that the drug imatinib inhibits enable cancer cells to be more resistant to the drug. A previous experimental study by the researchers found that these mutations increase the rate of drug unbinding from the protein. The study here describes computer simulations of the protein and explains why the mutations lead to increased dissociation kinetics. An advanced algorithm was used to sample ligand unbinding events in simulation.
I don’t have AirPods but this sometimes happens to me when I turn off my Bluetooth headphones. Usually it’s Spotify that begins playing on my computer. I agree that google searching has been unhelpful.
I use org mode by having a single file and using it as a notebook/journal. I use todos to mark important entries.
I’m comfortable with org mode operations and formatting although I don’t know how to use drawers or properties or what’s the point of archiving. I like using org-ref, and I see a version of that has been added officially this version.
I never learned a more clever way of using org mode. Any tips or guides?
But the use case is not the middle of the night but perhaps during evening rush hour where it gets dark after 5 PM in the winter, and a storm began in the afternoon.
The first idea seems like it would require a lot a lot of data stored in the car. Is it feasible? And even so, to be that dependent on matching up with existing pre-mapped data suggests a system that would be quite slow to roll out across a country.
> "I also really like timetables and I like the logistics of putting things together."
I enjoy that too. It's also essential if you don't have a car. I think it's a shame that Amtrak no longer has timetables for download. Maybe it's to hide the sad fact that there are only 10-15 trains per day in one direction on the northeast corridor.
I read the article as arguing the low hanging fruit are picked, and that performance can't quite make another leap. Can't bump up clock speed because it'll use more power or because the CPU design won't support it.
There isn't evidence that Apple's team has run out of architectural improvements however, so I do think performance gains are still out there. Plus there's always the possibility of going to smaller semiconductor processes.
I don't think you could get thousands of cycles, but you might be able to go from <500 to ~1000. Higher quality cells might achieve the same thing though. Apple guarantees 1000 cycles on its laptops, like a sister comment states.
Consider a Tesla that gets ~250 miles of range per full cycle. The battery would reach 1000 cycles after 250k miles of driving, at which point you have a pretty old car. Depending on factors like time, environmental conditions, driving style, a battery replacement might be necessary at some point in the car's life. So the batteries in EVs probably cannot sustain thousands of cycles. The battery capacity is large enough that the overall cycle count is reasonable within the lifespan of the vehicle, and the battery cooling system keeps degradation reasonable given the high demands EV batteries must fulfill.
I don't believe it. When I had a cheapo mountain bike, I could hear the tires on the road, especially at higher speeds. With my current road bike, the tires are a lot quieter. That noise translates into lost energy, including lost energy that can't be heard. Sure the bikes differ a lot, but the difference in rolling resistance is stark to me. The road bike also can roll for a lot longer a distance.
For me, what doesn't work is trying to write it out on the computer. Writing down thoughts requires a level of clarity that I might not have yet for a particular task. I find that a shower or other bathroom break helps to organize my thoughts. Walking outside is a bit too distracting.
I need to try to get up from my desk more when stuck. There's a bit of inertia to overcome in getting up from my seat, but it would probably be more efficient, thinking wise.
Miyoko's is good. Available at Whole Foods and even some products at Target. Miyoko cheddar-style cheese slices have a nice tang to them. The coconut oil and tapioca starch kind of stuff (Daiya, etc.) is alright for pizza, but it's not great. It's expensive too. This kind of stuff should be cheaper to make than dairy cheese. Unfortunately cheese and cheeze are both high in calories, sodium, and fat.
> To be clear, the potato is not, in and of itself, an energy source. What the potato does is simply help conduct electricity by acting as what’s called a salt-bridge between the the two metals, allowing the electron current to move freely across the wire to create electricity. Numerous fruits rich in electrolytes like bananas and strawberries can also form this chemical reaction. They're basically nature’s version of battery acid.
With programming, the average programmer is a paid professional. With weightlifting, even specialized to bodybuilding, the average participant is lifting for recreational reasons. I imagine the fraction of people who've competed at the amateur level in bodybuilding is a minority of the total people discussing the subject. So it depends on whether the author is interested in gauging opinion among the minority of competitive bodybuilders or among people just a little more dedicated to lifting weights than usual. The article reads as if the author wants to somehow survey opinions among the "bros."
I think weightlifting (and also nutrition) have an intersection between one's choices and the scientific literature. From what I've seen of bodybuilders on youtube, there are many that base their programs and recommendations on what they believe is scientifically optimal. In most other areas of personal decision-making, you won't find wisdom in academic literature. For instance, remodeling your kitchen or dating. You might seek out advice from various sources, but those sources probably wouldn't include academic research.
The other thing about this article is that in using forums and websites to gauge the view of the bodybuilding community, you end up sampling more dedicated people who are interested in this sort of discussion. There might be people following all sorts of weird stuff ("woo") based on what their buddies at the gym are doing.
I wonder whether there are political issues where the "literature" is ahead of where natural intuition is. For instance, the minimum wage. Microeconomic intuition says raising the minimum wage reduces the number of jobs available. I think there are lots of studies out there saying that this intuition is false. The minimum wage's effect on jobs is something fuzzier than scientific fact however, and it kind of falls outside the concept of metis too.
Also, the majority of comments here seem to be focused on the question of rest interval, but that's not the main point of the article as I see it.
That is, certain mutations in the protein that the drug imatinib inhibits enable cancer cells to be more resistant to the drug. A previous experimental study by the researchers found that these mutations increase the rate of drug unbinding from the protein. The study here describes computer simulations of the protein and explains why the mutations lead to increased dissociation kinetics. An advanced algorithm was used to sample ligand unbinding events in simulation.